Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

Marburg virus (MARV) has a high fatality rate in humans, causing hemorrhagic fever characterized by massive viral replication and dysregulated inflammation. Here, we demonstrate that VP24 of MARV binds Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear transcription factor...

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Үндсэн зохиолчид:	Audrey Page, Valentina A. Volchkova, Saint Patrick Reid, Mathieu Mateo, Audrey Bagnaud-Baule, Kirill Nemirov, Amy C. Shurtleff, Philip Lawrence, Oliver Reynard, Michele Ottmann, Vincent Lotteau, Shyam S. Biswal, Rajesh K. Thimmulappa, Sina Bavari, Viktor E. Volchkov
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2014-03-01
Цуврал:	Cell Reports
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2211124714001272
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!