Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes.

Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is known of the im...

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Hauptverfasser:	Pranav Kumar, Robert Lodge, Nathalie Trudel, Michel Ouellet, Marc Ouellette, Michel J Tremblay
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2010-03-01
Schriftenreihe:	PLoS Neglected Tropical Diseases
Online-Zugang:	http://europepmc.org/articles/PMC2846936?pdf=render
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