ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

Abstract Background N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear. Results In this investigation, we explored the involvement of m6A de...

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Hlavní autoři:	Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He, Xuenan Wang, Xingguo Li, Fan Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-06-01
Edice:	Cell & Bioscience
Témata:	m6A demethylation ALKBH5 YTHDF1 Runx2 MMP ADAMTS
On-line přístup:	https://doi.org/10.1186/s13578-024-01264-y
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