Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena group I intron ribozyme

Circular RNA (circRNA) has various advantages over linear mRNA that is gaining success as a new vaccine and therapeutic agent. Thus, circRNA and its engineering methods have attracted attention recently. In this study, we developed a new in vitro circRNA engineering method by end-to-end self-targeti...

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Principais autores:	Kyung Hyun Lee, Seongcheol Kim, Jaehwi Song, Seung Ryul Han, Ji Hyun Kim, Seong-Wook Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-09-01
coleção:	Molecular Therapy: Nucleic Acids
Assuntos:	MT: non-coding RNAs circular RNA mRNA self-circularization Tetrahymena group I intron
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S216225312300207X
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