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Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing

Abstract Background This study aimed to use single-cell RNA-seq (scRNA-seq) to discover marker genes in endothelial cells (ECs) and construct a prognostic model for glioblastoma multiforme (GBM) patients in combination with traditional high-throughput RNA sequencing (bulk RNA-seq). Methods Bulk RNA-...

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Autori principali: Songyun Zhao, Wei Ji, Yifan Shen, Yuansheng Fan, Hui Huang, Jin Huang, Guichuan Lai, Kemiao Yuan, Chao Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-12-01
Serie:BMC Cancer
Soggetti:
GBM
scRNA-seq
Risk score
Prognostic model
Immune cell infiltration
Accesso online:https://doi.org/10.1186/s12885-022-10305-z
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