High-yield spidroin mimics for bioinspired fibers via computational design

The exceptional mechanical properties, biocompatibility, and biodegradability of spider silk make it a promising biomaterial, yet large-scale production remains hindered by challenges in heterologous expression. Existing prokaryotic systems face bottlenecks due to spidroins’ high molecular weight, r...

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Hlavní autoři:	Yufan Huang, Junzi Qi, Bingrui An, Bensheng Zhang, Yukang Yang, Cheng Cheng, Bingfang He
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-04-01
Edice:	Frontiers in Bioengineering and Biotechnology
Témata:	spidroin β-sheet coarse-grained molecular dynamics Escherichia coli heterologous expression self-assembly
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1587546/full
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