Daidzein-engineered high-accumulation self-therapeutic nanoplatform drives androgen receptor degradation via ubiquitination-proteasome system to overcome enzalutamide resistance in castration-resistant prostate cancer

High levels of androgen receptor (AR) are associated with poor prognosis and drug resistance in castration-resistant prostate cancer (CRPC), and monotherapy with AR antagonists such as enzalutamide (Enz) is currently inadequate to meet the clinical needs. Dual-targeted therapeutic strategy of AR deg...

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Автори:	Zhaoxiang Xie, Chunlei Dai, Zhi Xiong, Minghui Li, Liying Wang, Junjia Xie, Xinyin Li, Yi Zhao, Kaiwen Li, Jun Wu, Hai Huang
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2026-02-01
Серія:	Materials Today Bio
Предмети:	Daidzein Phytoestrogens Androgen receptor Enzalutamide Castration-resistant prostate cancer
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S259000642501227X
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