Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefit

Abstract Aims Developing predictive biomarkers for immune checkpoint inhibitors (ICIs) is important. Programmed cell death protein-1 (PD-1) receptor occupancy by anti-PD-1 antibodies on circulating T cells varies among patients. However, the association between the exhaustion of these antibody-bound...

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Bibliografiske detaljer

Principais autores:	Toshiaki Tsurui, Masahiro Hosonuma, Aya Sasaki, Yuuki Maruyama, Yasunobu Amari, Eiji Funayama, Kohei Tajima, Hitoshi Toyoda, Junya Isobe, Yoshitaka Yamazaki, Yuta Baba, Midori Shida, Yuko Udaka, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Satoshi Wada, Atsuo Kuramasu, Mayumi Tsuji, Yuji Kiuchi, Takuya Tsunoda, Kiyoshi Yoshimura
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2025-03-01
Serier:	Discover Oncology
Fag:	Biomarker Exhaustion Ki-67 Memory T cells Immune checkpoint inhibitor PD-1/PD-L1 signaling
Online adgang:	https://doi.org/10.1007/s12672-025-02060-x
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