FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma

Abstract Genomic alterations that activate Fibroblast Growth Factor Receptor 2 (FGFR2) are common in intrahepatic cholangiocarcinoma (ICC) and confer sensitivity to FGFR inhibition. However, the depth and duration of response is often limited. Here, we conduct integrative transcriptomics, metabolomi...

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Autori principali:	Yuanli Zhen, Kai Liu, Lei Shi, Simran Shah, Qin Xu, Haley Ellis, Eranga R. Balasooriya, Johannes Kreuzer, Robert Morris, Albert S. Baldwin, Dejan Juric, Wilhelm Haas, Nabeel Bardeesy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-05-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-47514-y
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