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BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

The preservation of genome integrity during sperm and egg development is vital for reproductive success. During meiosis, the tumor suppressor BRCA1/BRC-1 and structural maintenance of chromosomes 5/6 (SMC-5/6) complex genetically interact to promote high fidelity DNA double strand break (DSB) repair...

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Main Authors: Erik Toraason, Alina Salagean, David E Almanzar, Jordan E Brown, Colette M Richter, Nicole A Kurhanewicz, Ofer Rog, Diana E Libuda
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2024-08-01
Series:eLife
Subjects:
meiosis
DNA repair
sister chromatid
recombination
DNA double strand breaks
germline
Online Access:https://elifesciences.org/articles/80687
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