A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction

Abstract Nicardipine is a calcium channel blocker employed to manage hypertension and angina. It is primarily metabolized in the liver; therefore, hepatic impairment patients may experience drug accumulation, potentially resulting in adverse events. This research aims to design physiologically based...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Ammara Ayub, Ammara Zamir, Muhammad Fawad Rasool, Usman Arshad, Faleh Alqahtani
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-06-01
Цуврал:	Scientific Reports
Нөхцлүүд:	Nicardipine PBPK model Hypertension Liver cirrhosis Renal impairment
Онлайн хандалт:	https://doi.org/10.1038/s41598-025-03829-4
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!