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Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability

Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed to develop and evaluate eplerenone nanocrystals (EPL-NCs) for solubility and dissolution enhancement. D-optimal combined mixture process using Desi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Muhammad Ayub Khan, Muhammad Mohsin Ansari, Sadia Tabassam Arif, Abida Raza, Ho-Ik Choi, Chang-Wan Lim, Ha-Yeon Noh, Jin-Su Noh, Salman Akram, Hafiz Awais Nawaz, Muhammad Ammad, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Jin-Ki Kim, Alam Zeb
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2021-01-01
Schriftenreihe:Drug Delivery
Schlagworte:
eplerenone
poorly aqueous solubility
nanocrystals
controlled crystallization
dissolution rate and bioavailability
acute toxicity study
Online-Zugang:http://dx.doi.org/10.1080/10717544.2021.2008051
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