Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

Abstract Background Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with age and neurodegeneration. One aspect of microglial dysfunction is redu...

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Главные авторы:	Ana Rubio-Araiz, Orla M. Finucane, Samuel Keogh, Marina A. Lynch
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2018-08-01
Серии:	Journal of Neuroinflammation
Предметы:	Toll-like receptor 2 (TLR2) Amyloid-β (Aβ) Microglia Neuroinflammation Glycolysis Oxidative metabolism
Online-ссылка:	http://link.springer.com/article/10.1186/s12974-018-1281-7
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