Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice

Abstract Background Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. IL-33 associated with innate immunity induces type 2 inflam...

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Hlavní autoři:	Atsushi Kurokawa, Mitsuko Kondo, Ken Arimura, Shigeru Ashino, Etsuko Tagaya
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-06-01
Edice:	Respiratory Research
Témata:	Airway hyperresponsiveness Asthma Eosinophils Goblet cell metaplasia IL-33 Innate immunity
On-line přístup:	https://doi.org/10.1186/s12931-021-01763-3
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