ATP-P2X7R pathway activation limits the Tfh cell compartment during pediatric RSV infection

BackgroundFollicular helper T cells (Tfh) are pivotal in B cell responses. Activation of the purinergic receptor P2X7 on Tfh cells regulates their activity. We investigated the ATP-P2X7R axis in circulating Tfh (cTfh) cells during Respiratory Syncytial Virus (RSV) infection.MethodsWe analyzed two co...

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Detalles Bibliográficos

Principais autores:	Constanza Russo, Silvina Raiden, Silvia Algieri, María José Bruera, Norberto De Carli, Mariam Sarli, Héctor Cairoli, Leonardo De Lillo, Ivanna Morales, Vanesa Seery, Adrián Otero, Inés Sananez, Nancy Simaz, Gisela Alfiero, Gabriela Rubino, Néstor Moya, Luisa Aedo Portela, Mauro Herrero, Marina Blanco, Misael Salcedo Pereira, Fernando Ferrero, Jorge Geffner, Lourdes Arruvito
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-07-01
Series:	Frontiers in Immunology
Assuntos:	children RSV ATP Tfh cell antibodies
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397098/full
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