Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity

Systemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell death induced by lurbinectedin reinstates and enhances systemic anticancer immune responses. Lurbinectedin treatment showed traits of imm...

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Autores principales:	Wei Xie, Sabrina Forveille, Kristina Iribarren, Allan Sauvat, Laura Senovilla, Yan Wang, Juliette Humeau, Maria Perez-Lanzon, Heng Zhou, Juan F. Martínez-Leal, Guido Kroemer, Oliver Kepp
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2019-11-01
Colección:	OncoImmunology
Materias:	anticancer immunity immunogenic cell death checkpoint blockade tumor clearance
Acceso en línea:	http://dx.doi.org/10.1080/2162402X.2019.1656502
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