Development and Evaluation of Liposomal <i>Celastrol</i>-PROTACs for Treating Triple-Negative Breast Cancer
<b>Background:</b> Based on our previous study, <i>Celastrol</i>-based proteolysis-targeting chimeras (<i>Celastrol</i>-PROTACs) were shown to induce apoptosis in 4T1 cells by selectively degrading GRP94 and CDK1/4 through the endogenous ubiquitin–proteasome system. However, their clinical translati...
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| Principais autores: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI AG
2025-09-01
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| Serier: | Pharmaceuticals |
| Fag: | |
| Online adgang: | https://www.mdpi.com/1424-8247/18/9/1381 |
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