Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Serine hydroxymethyltransferase 2 (SHMT2) converts serine to glycine in mitochondria and is upregulated in a variety of cancers. Here the authors show that acetylation of the lysine-95 (K95) residue negatively regulates SHMT2 expression and activity and is deacetylated by SIRT3 in colorectal cancer.

ग्रंथसूची विवरण

मुख्य लेखकों:	Zhen Wei, Jinglue Song, Guanghui Wang, Ximao Cui, Jun Zheng, Yunlan Tang, Xinyuan Chen, Jixi Li, Long Cui, Chen-Ying Liu, Wei Yu
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Nature Portfolio 2018-10-01
श्रृंखला:	Nature Communications
ऑनलाइन पहुंच:	https://doi.org/10.1038/s41467-018-06812-y
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