Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes through a Sirtuin 1 associated mechanism

Abstract Glucocorticoids such as dexamethasone (DEX) are commonly used clinically but can induce skeletal muscle atrophy with prolonged or high-dose exposure. Trichosanthes kirilowii Maximowicz (TK), a traditional medicinal herb, has known pharmacological effects, but its impact on muscle atrophy re...

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Hlavní autoři:	Hyunseong Kim, Jin Young Hong, Changhwan Yeo, Wan-Jin Jeon, Hyun Kim, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-12-01
Edice:	Scientific Reports
Témata:	C2C12 myotubes Sirtuin 1 Dexamethasone Muscle atrophy Trichosanthes kirilowii Maximowicz
On-line přístup:	https://doi.org/10.1038/s41598-025-28257-2
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