MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferon...

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Detalhes bibliográficos

Principais autores:	Siqi Liu, Jueqi Chen, Xin Cai, Jiaxi Wu, Xiang Chen, You-Tong Wu, Lijun Sun, Zhijian J Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2013-08-01
coleção:	eLife
Assuntos:	MAVS innate immunity virus ubiquitin signaling mitochondria
Acesso em linha:	https://elifesciences.org/articles/00785
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