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A scissor-guided single-cell framework defines a macrophage-derived risk score for prognostic and immunotherapy stratification in lung adenocarcinoma

BackgroundMacrophages are key regulators within the lung adenocarcinoma (LUAD) tumor microenvironment, and their functional states and interaction patterns are closely linked to prognosis and immunotherapy response. However, macrophage-associated risk models derived from single-cell features remain...

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Main Authors: Yueyue Shi, Linyue Hai, Guoqing Hou, Zhiqiang Wang, Lanju Wang, Zhenyu Lv, Xinjian Hao, Shiran Chen, Rong Xia, Junzheng Cao, Shujun Shao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-05-01
Series:Frontiers in Immunology
Subjects:
LUAD
machine learning
macrophage
SCISSOR
ScRNA-seq
TIMP1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1827555/full
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