TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

Abstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes. Contra...

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Auteurs principaux:	Thomas E Schultz, Carmen D Mathmann, Leslie C Domínguez Cadena, Timothy W Muusse, Hyoyoung Kim, James W Wells, Glen C Ulett, Jessica A Hamerman, Andrew J Brooks, Bostjan Kobe, Matthew J Sweet, Katryn J Stacey, Antje Blumenthal
Format:	Artigo
Langue:	Inglês
Publié:	Springer Nature 2025-04-01
Collection:	EMBO Reports
Sujets:	Macrophage TLR4 Signaling Endosome LPS
Accès en ligne:	https://doi.org/10.1038/s44319-025-00444-2
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