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High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern

SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally...

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Principais autores: Andres Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez, Andrés Hernández, María Herrera, Guillermo León, Román Macaya, Arne Kühne, José Arturo Molina-Mora, Javier Mora, Alfredo Sanabria, Andrés Sánchez, Laura Sánchez, Álvaro Segura, Eduardo Segura, Daniela Solano, Claudio Soto, Jennifer L. Stynoski, Mariángela Vargas, Mauren Villalta, Chantal B. E. M. Reusken, Christian Drosten, José María Gutiérrez, Alberto Alape-Girón, Jan Felix Drexler
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-09-01
coleção:Frontiers in Medicine
Assuntos:
equine antibodies
SARS-CoV-2
therapy
variant of concern
PRNT titers 50
neutralization test
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmed.2021.735853/full
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