Physiologically Based Pharmacokinetic–Pharmacodynamic-Based Quantification of Exposure–Response for Sodium Tanshinone IIA Sulfonate in Normal and Cerebral Ischemia–Reperfusion Injury Rats
Sodium tanshinone IIA sulfonate (STS) injection is clinically used to protect against cerebral ischemia–reperfusion injury (CIRI). This study aimed to establish physiologically based pharmacokinetic–pharmacodynamic (PBPK–PD) models for normal and CIRI rats and to quantitatively characterize the time...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2026-05-01
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| coleção: | Biology |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2079-7737/15/11/827 |
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