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Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Abstract Background Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a novel folate-aminopterin construct (EC2319) in a rat focal model of mult...

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Main Authors: Petri Elo, Xiang-Guo Li, Heidi Liljenbäck, Maria Gardberg, Olli Moisio, Maxwell Miner, Jenni Virta, Antti Saraste, Madduri Srinivasarao, Michael Pugh, Philip S. Low, Juhani Knuuti, Sirpa Jalkanen, Laura Airas, Yingjuan June Lu, Anne Roivainen
Format: Artigo
Language:Inglês
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Aminopterin
Folate receptor
Experimental autoimmune encephalomyelitis
Inflammation
Macrophages
Multiple sclerosis
Online Access:https://doi.org/10.1186/s12974-021-02073-7
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