Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

Abstract The tumor cell-intrinsic cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is critical for activating anti-tumor immunity and enhancing immune checkpoint blockade therapy in colorectal cancer (CRC). Cancer-associated fibroblasts (CAFs), key components of the CRC...

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Detalhes bibliográficos

Principais autores:	Ryo Kanoda, Shotaro Nakajima, Hirokazu Okayama, Akinao Kaneta, Shun Chida, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Yuya Maruyama, Hiroya Suzuki, Kosaku Mimura, Motonobu Saito, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-06-01
coleção:	Scientific Reports
Assuntos:	Colorectal cancer Cancer-associated fibroblast Versican Tumor cell-intrinsic cGAS–STING
Acesso em linha:	https://doi.org/10.1038/s41598-025-03924-6
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