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450 million years in the making: mapping the evolutionary foundations of germinal centers

Germinal centers (GCs) are distinct microanatomical structures that form in the secondary lymphoid organs of endothermic vertebrates (i.e., mammals and some birds). Within GCs, B cells undergo a Darwinian selection process to identify clones which can respond to pathogen insult as well as affinity m...

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Autori principali: Hanover Matz, Helen Dooley
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-08-01
Serie:Frontiers in Immunology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1245704/full
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