Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

ABSTRACT Current cancer therapies inhibit tumor growth but fail to target metastatic dissemination. Obscurin (720–870 kDa), a giant signaling protein localizing to the breast epithelial cell membrane, is a metastasis suppressor commonly lost in breast cancer. Obscurin loss upregulates the oncogenic...

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Detalhes bibliográficos

Principais autores:	Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-05-01
coleção:	Advanced Science
Assuntos:	breast cancer metastasis suppressors obscurin PI3K/Akt signaling PI3K inhibitors pleckstrin homology domains
Acesso em linha:	https://doi.org/10.1002/advs.202518339
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