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Evaluation of the Drug–Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling

<b>Background:</b> Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide. Morphine is the gold standard for chronic pain management and has a...

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Principais autores: Shelby Coates, Keti Bardhi, Bhagwat Prasad, Philip Lazarus
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-12-01
coleção:Pharmaceutics
Assuntos:
physiologically based pharmacokinetic modeling (PBPK)
UDP-glucuronosyltransferase (UGT)
cannabidiol
cannabinoid
morphine
IVIVE
Acesso em linha:https://www.mdpi.com/1999-4923/16/12/1599
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