TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury

Abstract Background Necroptosis of macrophages is a necessary element in reinforcing intrapulmonary inflammation during acute lung injury (ALI). However, the molecular mechanism that sparks macrophage necroptosis is still unclear. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a patter...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Wen-Jing Zhong, Jun Zhang, Jia-Xi Duan, Chen-Yu Zhang, Sheng-Chao Ma, Yu-Sheng Li, Nan-Shi-Yu Yang, Hui-Hui Yang, Jian-Bing Xiong, Cha-Xiang Guan, Zhi-Xing Jiang, Zhi-Jian You, Yong Zhou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-03-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Acute lung injury TREM-1 Macrophages Necroptosis Mitochondrial fission mTOR
Online-Zugang:	https://doi.org/10.1186/s12967-023-04027-4
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