Population structure and emergence of resistance to new and repurposed drugs in XDR-TB: insights from a 10-year genomic study in the Western Cape, South Africa review

BackgroundExtensively drug-resistant tuberculosis (XDR-TB) is a global health threat, being expensive and difficult to treat, with high mortality rates. The Western Cape Province (WCP), South Africa, has a particularly high burden of XDR-TB (>800 cases in the past ten years). Drug resistance geno...

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Principais autores:	Justice Tresor Ngom, Johannes Loubser, Elizna Maasdorp, Yonas Ghebrekristos, Sarishna Singh, Christoffel J. Opperman, Marisa Klopper, Robin Mark Warren, Elizabeth M. Streicher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-09-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	genomic characterisation extensively drug-resistant tuberculosis whole genome sequencing transmission new and repurposed drugs South Africa
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1638577/full
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