Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine

Summary: The development of a Zika virus (ZIKV) vaccine is complicated by the high homology between ZIKV and dengue virus (DENV) envelope (E) proteins, resulting in immunological cross-reactivity that can exacerbate disease through antibody-dependent enhancement (ADE). Here, we screen 121 anti-DENV...

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Principais autores:	Ariadna Grinyo-Escuer, Srikar Reddy, Agnes L. Chenine, J. Charles Whitbeck, Sonya Jacobsen, Allison Sheetz, Kyle Doolan, Diana M. Norden, Nolan Frey, Frederick W. Holtsberg, M. Javad Aman, Katja Fink, Michael S. Diamond, John S. Schieffelin, James E. Crowe, Jr., Edgar Davidson, Benjamin J. Doranz
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-08-01
Serija:	Cell Reports
Teme:	CP: Immunology CP: Microbiology
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124725008691
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