The Emerging Role of N-Lactoyl-Phenylalanine (Lac-Phe) in Metabolic Regulation and Disease: From Exercise-Induced Metabolite to Therapeutic Candidate

N-Lactoyl-phenylalanine (Lac-Phe), identified in 2022 as an exercise-inducible signaling metabolite, is formed by carnosine dipeptidase 2 via conjugation of lactate and phenylalanine. Its circulating levels rise sharply after intense exercise in mice, humans, and racehorses, reflecting increased gly...

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Hlavní autoři:	Julia Chu-Ning Hsu, Chia-Hui Chen, Ming-Wei Chen, Wen-Hua Chen, Tzong-Shyuan Lee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-04-01
Edice:	Antioxidants
Témata:	N-lactoyl-phenylalanine exerkine appetite suppression obesity mitochondrial dysfunction metformin
On-line přístup:	https://www.mdpi.com/2076-3921/15/4/441
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