क्यूआर कोड

Understanding interspecies drug response variations between human and rodent P2X7 receptors

Abstract Despite intensive development, P2X7 modulators have struggled in translation due to human genetic variability and species-dependent drug responses. Here, we identify PSFL1191, a portal-of-central-pocket (PCP)-site inhibitor selective for human and panda P2X7, but inactive against rodents. C...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Chang-Run Guo, Danqi Sheng, Ji-Yuan Li, Tian-Tian Li, Jia-Bao Yao, Rui Zhang, Ye Huang, Ying-Ying Zhao, Dong-Ping Wang, Jie Chen, Jian Li, Jiang Wang, Yu Zhou, Cheng Shen, Fei Jin, Peng Cao, Motoyuki Hattori, Hong Liu, Ye Yu
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Portfolio 2025-12-01
श्रृंखला:Nature Communications
ऑनलाइन पहुंच:https://doi.org/10.1038/s41467-025-65847-0
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