High expression of LncRNA HOTAIR is a risk factor for temozolomide resistance in glioblastoma via activation of the miR-214/β-catenin/MGMT pathway

Abstract HOX transcript antisense RNA (HOTAIR) is upregulated in glioblastoma (GBM) and associated with temozolomide (TMZ) resistance. However, the mechanisms underlying HOTAIR-mediated TMZ resistance remains poorly understood. HOTAIR expression in glioma-related public datasets and drug response es...

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Detalhes bibliográficos

Principais autores:	Tian Lan, Wei Quan, Dong-Hu Yu, Xi Chen, Ze-Fen Wang, Zhi-Qiang Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-10-01
Colecção:	Scientific Reports
Assuntos:	lncRNA HOTAIR Temozolomide Resistance Β-catenin Methotrexate
Acesso em linha:	https://doi.org/10.1038/s41598-024-77348-z
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