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Enhancement of in vivo hypoglycemic effect of gliclazide by developing self-microemulsifying pellet dosage form

Abstract Background The present research was aimed to develop a self-microemulsifying drug delivery system (SMEDDS) pellet to increase the dissolution rate and in vivo hypoglycemic effect of gliclazide. Gliclazide belongs to BCS class 2 and it exhibits dissolution rate-limited absorption. Thus, diss...

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Principais autores: Hetal Patel, Niharika Pandey, Bhoomi Patel, Ketan Ranch, Kunjan Bodiwala, Bhavin Vyas
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2020-05-01
coleção:Future Journal of Pharmaceutical Sciences
Assuntos:
SMEDDS
Hypoglycemic
Tween
Pellets
Extrusion
Dissolution
Acesso em linha:http://link.springer.com/article/10.1186/s43094-020-00034-0
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