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LncRNA HOTAIR-mediated MTHFR methylation inhibits 5-fluorouracil sensitivity in esophageal cancer cells

Abstract Background Esophageal cancer (EC) represents one of the most aggressive digestive neoplasms globally, with marked geographical variations in morbidity and mortality. Chemoprevention is a promising approach for cancer therapy, while acquired chemoresistance is a major obstacle impeding the s...

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Main Authors: Shuyao Zhang, Fuchun Zheng, Liqun Zhang, Zuojun Huang, Xiaoshan Huang, Zhen Pan, Shuang Chen, Chenchen Xu, Yi Jiang, Shuyi Gu, Chengkuan Zhao, Qiuzhen Zhang, Ganggang Shi
Format: Artigo
Language:Inglês
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Esophageal cancer
lncRNA HOTAIR
MTHFR
5-fluorouracil
Chemosensitivity
Online Access:http://link.springer.com/article/10.1186/s13046-020-01610-1
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