Disulfiram inhibits Gasdermin D pores formation and improves insulin-dependent glucose uptake and glucose homeostasis in skeletal muscle of obesity-induced insulin-resistant mice

Abstract Insulin resistance (IR), which involves impaired insulin signaling diminished insulin sensitivity in skeletal muscle, is closely associated with chronic low-grade inflammation. A key mediator of this process is the NLRP3 inflammasome, which activates Gasdermin D (GSDMD). Upon cleavage, the...

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Hlavní autoři:	Cynthia Cadagan, Javier Russell-Guzmán, Luan Américo-Da-Silva, Paula Montaña, Genaro Barrientos, Sonja Buvinic, Gladys Tapia, Manuel Estrada, Paola Llanos
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-11-01
Edice:	Scientific Reports
Témata:	GSDMD-NT Glucose uptake IL-1β release Insulin signaling NALP3 inflammasome
On-line přístup:	https://doi.org/10.1038/s41598-025-30058-6
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