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Switchbody, an Antigen‐Responsive Enzyme Switch Based on Antibody and Its Working Principle

Abstract An enzyme switch, termed “Switchbody”, is developed by fusing an antibody with a fragment of a split enzyme for the precise regulation of enzyme activity in response to an antigen. A luciferase‐based Switchbody is engineered by fusing the NanoLuc luciferase fragment HiBiT to the N‐terminus...

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Principais autores: Takanobu Yasuda, Yoshiyuki Ueno, Masahiko Taguchi, Naoya Tochio, Hiromasa Yagi, Shuma Yazaki, Ryoichi Arai, Bo Zhu, Takanori Kigawa, Hiroshi Ueda, Tetsuya Kitaguchi
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-11-01
coleção:Advanced Science
Assuntos:
antibodies
enzyme switch
immunosensors
molecular dynamics
protein structures
Acesso em linha:https://doi.org/10.1002/advs.202508422
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