A Multi‐Functional Nanoadjuvant Coupling Manganese with Toll‐Like 9 Agonist Stimulates Potent Innate and Adaptive Anti‐Tumor Immunity

Abstract The effectiveness of Toll‐like 9 agonists (CpG) as an adjuvant for tumor immunotherapy is restricted due to their insufficient ability to activate anti‐tumor immunity. To address that, the common nutrient metal ions are explored (Mn2+, Cu2+, Ca2+, Mg2+, Zn2+, Fe3+, and Al3+), identifying Mn...

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Detalhes bibliográficos

Principais autores:	Zhongjie Liu, Shu Li, Yang Xiao, Xiaoyang Liu, Bin Zhang, Qin Zeng, Qiang Ao, Xingdong Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-11-01
coleção:	Advanced Science
Assuntos:	manganese nanoadjuvant TLR9 agonist tumor immunotherapy vaccine
Acesso em linha:	https://doi.org/10.1002/advs.202402678
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