The ErbB-tyrosine kinase inhibitor, neratinib, has anti-inflammatory effects in multimorbidity by increasing macrophage efferocytosis via the upregulation of MerTK

Abstract Background Chronic inflammatory disease is responsible for huge and increasing global mortality and morbidity. Unregulated inflammatory cells, including neutrophils and macrophages, are major drivers of chronic inflammatory disease. Efferocytosis plays a critical role in inflammation resolu...

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Detalhes bibliográficos

Principais autores:	Kieran A. Bowden, Carl Wright, Susan Clark, Tomas Fernandez Correa, Simon A. Johnston, Helen M. Marriott, Sheila E. Francis, Lynne R. Prince
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
Colecção:	Journal of Inflammation
Assuntos:	Neutrophils Macrophages Inflammation Lung disease Multimorbidity Efferocytosis
Acesso em linha:	https://doi.org/10.1186/s12950-026-00495-9
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