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The ErbB-tyrosine kinase inhibitor, neratinib, has anti-inflammatory effects in multimorbidity by increasing macrophage efferocytosis via the upregulation of MerTK

Abstract Background Chronic inflammatory disease is responsible for huge and increasing global mortality and morbidity. Unregulated inflammatory cells, including neutrophils and macrophages, are major drivers of chronic inflammatory disease. Efferocytosis plays a critical role in inflammation resolu...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Kieran A. Bowden, Carl Wright, Susan Clark, Tomas Fernandez Correa, Simon A. Johnston, Helen M. Marriott, Sheila E. Francis, Lynne R. Prince
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-03-01
Schriftenreihe:Journal of Inflammation
Schlagworte:
Neutrophils
Macrophages
Inflammation
Lung disease
Multimorbidity
Efferocytosis
Online-Zugang:https://doi.org/10.1186/s12950-026-00495-9
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