Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

Abstract Background Malignant pleural mesothelioma (MPM) has a poor overall survival with few treatment options. Whole genome sequencing (WGS) combined with the immune features of MPM offers the prospect of identifying changes that could inform future clinical trials. Methods We analysed somatic mut...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Jenette Creaney, Ann-Marie Patch, Venkateswar Addala, Sophie A. Sneddon, Katia Nones, Ian M. Dick, Y. C. Gary Lee, Felicity Newell, Ebony J. Rouse, Marjan M. Naeini, Olga Kondrashova, Vanessa Lakis, Apostolos Nakas, David Waller, Annabel Sharkey, Pamela Mukhopadhyay, Stephen H. Kazakoff, Lambros T. Koufariotis, Aimee L. Davidson, Priya Ramarao-Milne, Oliver Holmes, Qinying Xu, Conrad Leonard, Scott Wood, Sean M. Grimmond, Raphael Bueno, Dean A. Fennell, John V. Pearson, Bruce W. Robinson, Nicola Waddell
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-05-01
Colecção:	Genome Medicine
Assuntos:	Malignant pleural mesothelioma Whole genome sequencing RNA sequencing Mutational signatures Tumour micro-environment Immunotherapy
Acesso em linha:	https://doi.org/10.1186/s13073-022-01060-8
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!