SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation

Abstract SARS-CoV-2 NSP14, an N7-guanosine methyltransferase, plays a critical role in viral RNA capping, enabling viral replication and immune evasion. While NSP14 has emerged as a promising drug target, its role in host-virus crosstalk and the cellular consequences of NSP14 inhibition remain poorl...

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Bibliografische Detailangaben

Hauptverfasser:	Mengxin Luo, Jun Mo, Ziqiao Wang, Huimin Wei, Kexin Chen, Liteng Shen, Ying Wang, Linjie Li, Yongkang Chen, Weihao Chen, Xue Li, Hui Feng, Xinyu Wang, Huan Zhou, Bizhi Li, Feng Xu, Qingwei Zhao, Yichen Xu, Jinxin Che, Peng Zou, Rong Zhang, Xiaowu Dong, Wei Xie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-11-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-025-64674-7
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