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IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in MiceSummary

Background & Aims: The liver has a distinct capacity to induce immune tolerance to hepatic antigens. Although liver tolerance can be advantageous for preventing autoimmune and inflammatory diseases, it also can be detrimental by preventing immune surveillance of infected or malignant cells. Here...

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Principais autores: Daria Krzikalla, Alena Laschtowitz, Lisa Leypoldt, Cornelia Gottwick, Pia Averhoff, Sören Weidemann, Ansgar W. Lohse, Samuel Huber, Christoph Schramm, Dorothee Schwinge, Johannes Herkel, Antonella Carambia
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-01-01
coleção:Cellular and Molecular Gastroenterology and Hepatology
Assuntos:
Hepatic Tolerance
Regulatory T Cells
Immune Checkpoints
Co-inhibition
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352345X23001686
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