Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score

Abstract Identifying genetic drivers of chronic diseases is necessary for drug discovery. Here, we develop a machine learning-assisted genetic priority score, which we call ML-GPS, that incorporates genetic associations with predicted disease phenotypes to enhance target discovery. First, we constru...

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Prif Awduron:	Robert Chen, Áine Duffy, Ben O. Petrazzini, Ha My Vy, David Stein, Matthew Mort, Joshua K. Park, Avner Schlessinger, Yuval Itan, David N. Cooper, Daniel M. Jordan, Ghislain Rocheleau, Ron Do
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2024-10-01
Cyfres:	Nature Communications
Mynediad Ar-lein:	https://doi.org/10.1038/s41467-024-53333-y
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