A fibroblast-specific gene signature as a therapeutic target for glioblastoma developed based on the characteristics of tumor microenvironment

Abstract Background This study identified fibroblast-specific genes to develop a RiskScore model to improve prognostic accuracy and guide personalized treatment in glioblastoma (GBM). Methods We analyzed fibroblast-specific signatures in the GSE273274 cohort using “Seurat” R package for scRNA-seq da...

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Bibliografische Detailangaben

Hauptverfasser:	Nan Liu, Mingyue Zhao, Yeting Cui, Jiaxuan Zhao, Yanyang Tu, Tongcun Zhang, Xiaofei Hu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	European Journal of Medical Research
Schlagworte:	Glioblastoma scRNA-seq analysis Fibroblasts signature Prognosis Drug sensitivity
Online-Zugang:	https://doi.org/10.1186/s40001-025-03528-w
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