Decoding epigenetic and transcriptional landscapes: DNA methylome-transcriptome integration reveals novel drivers in 4NQO-Induced esophageal squamous cell carcinoma mouse model

Abstract Background Epigenetic alterations, particularly DNA methylation, and dysregulation of the tumor immune microenvironment (TIME) are increasingly recognized as critical factors in esophageal squamous cell carcinoma (ESCC) pathogenesis. Understanding the dynamic interplay between DNA methylati...

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Ngā kaituhi matua:	Yanli Qian, Runhua Lin, Zhiwei Liu, Xinxin Zhang, Dongming Lin, Min Su
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-12-01
Rangatū:	Clinical Epigenetics
Ngā marau:	Esophageal squamous cell carcinoma DNA methylation RNA-seq Tumor immune microenvironment
Urunga tuihono:	https://doi.org/10.1186/s13148-025-02035-3
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!