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Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

The bacterium <i>Clostridium botulinum</i> is the causative agent of botulism&#8212;a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel <i>C. botulinum</i> immunotherapeutics, camelid single-domain antibodies (s...

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Principais autores: Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-08-01
Serier:Toxins
Fag:
camelid single-domain antibodies
VHH
<i>Clostridium botulinum</i>
toxin neutralization
phage display
dimers
Fc fragments
Online adgang:https://www.mdpi.com/2072-6651/11/8/464
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