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Sodium channels as a new target for pain treatment

Voltage-gated sodium channels, especially the Nav1.7, Nav1.8, and Nav1.9 subtypes, play a crucial role in the transmission of pain signals. Nav1.7 is considered a threshold channel that regulates the generation of action potentials and is closely associated with various hereditary pain disorders. Na...

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Autori principali: Rui Chen, Yiran Liu, Liu Qian, Mingliang Yi, Hong Yin, Shun Wang, Bingbing Xiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-03-01
Serie:Frontiers in Pharmacology
Soggetti:
pain
sodium channels
drug discovery
Nav1.7
Nav1.8
Nav1.9
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2025.1573254/full
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