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Construction and validation of gene signature for prognosis and drug sensitivity in cholangiocarcinoma based on cellular senescence related genes

Abstract Cholangiocarcinoma is a very deadly epithelial cell cancer with poor clinical outcome. Cellular senescence plays a vital role in the oncogenesis and the aggressiveness of cholangiocarcinoma. Integrative machine learning procedure including 10 methods (random survival forest, elastic network...

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Hlavní autoři: Chao Guo, Dan Liu, Tongyu Liu, Ting Dai, Weimin Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-11-01
Edice:Scientific Reports
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On-line přístup:https://doi.org/10.1038/s41598-025-27941-7
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